The role of mTOR signaling pathway in regulating autophagy in liver injury of TX mice with Wilson’s disease

Wilson disease (WD), known as hepatolenticular degeneration (HLD), is a treatable autosomal recessive disorder of copper metabolism. Because deposits in the liver first, not only original defective organ but also most affected organ. The injury one main causes death throughout course disease. Therefore, treatment task WD treatment, which great significance to improve prognosis patients. Autophagy process that promotes cell survival through degradation, recycling, and absorption order maintain normal physiological function cells, while excessive autophagy can aggravate death. In view abnormal damage cells patients with WD, may be related change level, this study, we established an animal model toxic milk (TX) mice, observed level liver, mice after inhibitors. It was found mTOR signaling pathway activated inhibited mouse liver. After rapamycin, upregulated, content reduced, alleviated. TX hepatocytes were isolated, using siRNA interfere expression, accumulation significantly same RAPA treatment. results showed caused by decrease activation pathway. Our findings suggested or use targeting have potential applications Wilson’s